The germ is nothing; the terrain is everything – Antoine Bechamp
Why some tissues are more vulnerable to infections than others?
Every living organism is a biologically non-homogenous environment. Tissues make specific environments, which are friendly for some microbes and unfriendly for others. Tissues are microbiologically diverse because they perform different functions in a living organism.
For example - striated muscular tissue transforms the energy stored in carbohydrates into mechanical and thermal energy. Therefore the concentration of these organic compounds in such a tissue is lower than in other tissues. The concentration of carbon dioxide, a metabolic product, is higher than elsewhere. Conclusion? Muscles are less vulnerable to infections with microbes that feed on carbohydrates.
Every surplus of glucose in systemic fluids is picked up by the skeletal muscle tissue and stored (with use of insulin) in muscular cells in a form of glycogen. This also decreases the concentration of the glucose and increases the resistance of this tissue to microbes feeding on sugars. The environment of human tissues producing mechanical and thermal energy considerably limits expansion capabilities of all microbes in these tissues. They have less to feed on than in other tissues.
Skin and fatty tissue effectively protect muscles against direct infection with microbes coming from the natural environment. But muscular tissues can be infected not only through an open wound. Internal injuries such as muscular strains or contusions, which are not accompanied by rupture of the skin, can also lead to infection.
Why? In the case of a critical overload of a muscle, the continuity of cell membranes in the muscular tissue is mechanically broken and contents of affected cells spill out. Now it makes an easier target for infection. When not protected by the cell membrane, the organic matter is a better environment for the microbes present in systemic fluids than the active cells of the tissue.
Provoking active movement of an internally injured, aching muscle is beneficial to it. Activity of the injured muscle allows for faster biodegradation of the remnants by the healthy cells and this way the probability of infection in this area is decreased. The concentration of the remnants in the injured muscle is reduced when the muscle is active.
Another example of different vulnerability for infection of different tissues. The susceptibility of the nervous tissue to microbes feeding on sugars is low. Transformation of the energy contained mainly in saccharides into the energy of electric nerve impulses effectively protects the nervous tissue against infections. Higher intensity of functioning of the nervous system increases the resistance of this tissue to infections. This is because sugar is used for the production of electric energy and less sugar is available for microbes. A fragment of the nerve tissue, which is damaged by an ischemic stroke is more susceptible to infections with, for example, Fusarium or Aspergillus. Why? Because these microbes feed mainly on lipids and amino acids that remain after a degradation of nerve cells. Microbes that are present in blood can find a friendly environment in the post-stroke necrotic area, develop there and continue to infect blood and other tissues. This can lead to a lethal condition called sepsis.
Our body also contains tissues which transform some organic compounds into another. Transforming common organic substances in tissues into compounds which are not so common in the natural environment does not increase the susceptibility of the tissue to infections.
It is a problem for a living organism to protect organic secretions produced by exocrine glands against microbes. Spaces in the breast, prostate, gallbladder, urinary bladder and kidneys that are filled with organic substances constitute a friendly environment for microbes. Long-lasting presence of microbes in milk, sperm, bile or urine can lead to penetration of microbes into the tissues producing these secretions, induce inflammation or cause neoplastic lesions. It is possible to limit the size of microbe population: in urine, by increased supply of water to the body, in the sperm, by frequent sexual intercourses, in bile, by a fat diet.
Tissues that remain in contact with the natural environment by a largest surface area include the lungs, digestive tract and skin. Microbes penetrate our bodies mainly through discontinuities in these tissues. Such wounds are frequently caused by flatworms, roundworms and insects that feed on human blood.
Blood usually has no direct contact with the natural external environment, therefore it is almost exclusively exposed to the microbes present inside the body. Blood reaches most of body tissues, where it is infected and can spread its infections to healthy tissues.
Plasma, which constitutes approximately 55% of blood volume is a perfect environment for human cells as well as for microbes. This is because it is a biologically non-organized organic substance, which is unprotected by biological membranes.
The lymph mainly consists of organic substances which are unprotected by cell membranes and constitutes a friendly environment for microbes. The immune system directly protects the plasma and the lymph against pathogens. It has a limited capacity, however, and is not able to provide sterility of the lymph and plasma in a body.
Metabolites dissolved in the plasma and lymph, produced by microbes living in the body, often support the immune system in the maintenance of homeostasis. Why? Because microbes are often in antagonism. The most famous example is antagonism between certain bacteria and mold Penicillium. They keep one another in check.
Sepsis, an extreme collapse of homeostasis, can be caused by inappropriate antibiotic therapy. Giving a patient even a small dose of an improperly selected antibiotic can be devastating. A theraphy that inadvertently destroys one of the antagonistic microbes may leave the door open for the other.
Currently, the problem of the so-called "healthcare-associated infections" does not result from ineffective aseptics, but rather misdirected antibiotic therapies in hospitals.
Extensive burns or lacerated wounds associated with severe damage of tissues are environments rich in necrotic areas, which is an easy nutrient for microbes present in the body. In such cases, sepsis can be caused by microbes coming from the natural environment or microbes that were already present inside the body.
Contemporary medicine neglects the significance of microbes living in patients' bodies during their recovery.
Any delay in surgical removal of necrosis maintains high quantities of organic substances at the damaged tissues and increases the risk of sepsis (especially in severely infected patients).
Our eyeballs are protected against microbes that are present in the natural environment by the eyelids and the lacrimal glands. The unconditional blinking reflex distributes a secretion of the lacrimal glands all over the corneas and the conjunctivas. The short break between two blinks interrupts any potential microbial incubation process on the surface of the eyes.
For example - striated muscular tissue transforms the energy stored in carbohydrates into mechanical and thermal energy. Therefore the concentration of these organic compounds in such a tissue is lower than in other tissues. The concentration of carbon dioxide, a metabolic product, is higher than elsewhere. Conclusion? Muscles are less vulnerable to infections with microbes that feed on carbohydrates.
Every surplus of glucose in systemic fluids is picked up by the skeletal muscle tissue and stored (with use of insulin) in muscular cells in a form of glycogen. This also decreases the concentration of the glucose and increases the resistance of this tissue to microbes feeding on sugars. The environment of human tissues producing mechanical and thermal energy considerably limits expansion capabilities of all microbes in these tissues. They have less to feed on than in other tissues.
Skin and fatty tissue effectively protect muscles against direct infection with microbes coming from the natural environment. But muscular tissues can be infected not only through an open wound. Internal injuries such as muscular strains or contusions, which are not accompanied by rupture of the skin, can also lead to infection.
Why? In the case of a critical overload of a muscle, the continuity of cell membranes in the muscular tissue is mechanically broken and contents of affected cells spill out. Now it makes an easier target for infection. When not protected by the cell membrane, the organic matter is a better environment for the microbes present in systemic fluids than the active cells of the tissue.
Provoking active movement of an internally injured, aching muscle is beneficial to it. Activity of the injured muscle allows for faster biodegradation of the remnants by the healthy cells and this way the probability of infection in this area is decreased. The concentration of the remnants in the injured muscle is reduced when the muscle is active.
Another example of different vulnerability for infection of different tissues. The susceptibility of the nervous tissue to microbes feeding on sugars is low. Transformation of the energy contained mainly in saccharides into the energy of electric nerve impulses effectively protects the nervous tissue against infections. Higher intensity of functioning of the nervous system increases the resistance of this tissue to infections. This is because sugar is used for the production of electric energy and less sugar is available for microbes. A fragment of the nerve tissue, which is damaged by an ischemic stroke is more susceptible to infections with, for example, Fusarium or Aspergillus. Why? Because these microbes feed mainly on lipids and amino acids that remain after a degradation of nerve cells. Microbes that are present in blood can find a friendly environment in the post-stroke necrotic area, develop there and continue to infect blood and other tissues. This can lead to a lethal condition called sepsis.
Our body also contains tissues which transform some organic compounds into another. Transforming common organic substances in tissues into compounds which are not so common in the natural environment does not increase the susceptibility of the tissue to infections.
It is a problem for a living organism to protect organic secretions produced by exocrine glands against microbes. Spaces in the breast, prostate, gallbladder, urinary bladder and kidneys that are filled with organic substances constitute a friendly environment for microbes. Long-lasting presence of microbes in milk, sperm, bile or urine can lead to penetration of microbes into the tissues producing these secretions, induce inflammation or cause neoplastic lesions. It is possible to limit the size of microbe population: in urine, by increased supply of water to the body, in the sperm, by frequent sexual intercourses, in bile, by a fat diet.
Tissues that remain in contact with the natural environment by a largest surface area include the lungs, digestive tract and skin. Microbes penetrate our bodies mainly through discontinuities in these tissues. Such wounds are frequently caused by flatworms, roundworms and insects that feed on human blood.
Blood usually has no direct contact with the natural external environment, therefore it is almost exclusively exposed to the microbes present inside the body. Blood reaches most of body tissues, where it is infected and can spread its infections to healthy tissues.
Plasma, which constitutes approximately 55% of blood volume is a perfect environment for human cells as well as for microbes. This is because it is a biologically non-organized organic substance, which is unprotected by biological membranes.
The lymph mainly consists of organic substances which are unprotected by cell membranes and constitutes a friendly environment for microbes. The immune system directly protects the plasma and the lymph against pathogens. It has a limited capacity, however, and is not able to provide sterility of the lymph and plasma in a body.
Metabolites dissolved in the plasma and lymph, produced by microbes living in the body, often support the immune system in the maintenance of homeostasis. Why? Because microbes are often in antagonism. The most famous example is antagonism between certain bacteria and mold Penicillium. They keep one another in check.
Sepsis, an extreme collapse of homeostasis, can be caused by inappropriate antibiotic therapy. Giving a patient even a small dose of an improperly selected antibiotic can be devastating. A theraphy that inadvertently destroys one of the antagonistic microbes may leave the door open for the other.
Currently, the problem of the so-called "healthcare-associated infections" does not result from ineffective aseptics, but rather misdirected antibiotic therapies in hospitals.
Extensive burns or lacerated wounds associated with severe damage of tissues are environments rich in necrotic areas, which is an easy nutrient for microbes present in the body. In such cases, sepsis can be caused by microbes coming from the natural environment or microbes that were already present inside the body.
Contemporary medicine neglects the significance of microbes living in patients' bodies during their recovery.
Any delay in surgical removal of necrosis maintains high quantities of organic substances at the damaged tissues and increases the risk of sepsis (especially in severely infected patients).
Our eyeballs are protected against microbes that are present in the natural environment by the eyelids and the lacrimal glands. The unconditional blinking reflex distributes a secretion of the lacrimal glands all over the corneas and the conjunctivas. The short break between two blinks interrupts any potential microbial incubation process on the surface of the eyes.
How to treat endometriosis then?
Maintaining high concentrations of organic substances for a longer time in the proximity of endometrium exposes this tissue to infections with microbes that are present in the natural environment and in the body.
In order to discontinue a potential microbial incubation process in the functional layer of the endometrium, the latter one periodically exfoliates which is manifested as menstruation.
Menstruation triggers hormonally-induced ischemia in the endometrium, which leads to a decomposition of the cells of the external layer of endometrium. Thanks to this process a biologically dangerous load can be removed outside the uterus and vagina.
A decomposition of cells caused by an ischemia in the functional layer of the endometrium causes a temporary increase in the already large quantity of organic substances in the endometrium.
Any potential infection in the inner, basal layer of endometrium can develop very quickly, using the organic reserves intended for the embryo and the necrosis resulting from ischemia in the functional part of the endometrium. A sudden, cyclic development of infection in the endometrium and the neighbouring tissues that coincides with ischemia in the endometrium causes acute pain.
In an infected body, menstruation which is supposed to protect women against infections in the reproductive system and provide an embryo with a microbe-free environment, may not fulfil its protective function. It can harm both the mother and her baby.
The claim that endometriosis is caused by environmental factors can be justified by the following facts:
- Antibiotic therapies affect the endometrium: they can restrict the development of a disease, sometimes allowing for natural pregnancy, but they can also aggravate the development of the disease if the therapy is inappropriately selected.
- Aggravated development of an infection in the basal layer of the endometrium can be associated with necrosis in the functional layer of endometrium - that is with menstruation.
- The currently used surgical and hormonal therapies for the treatment of endometriosis are not effective and ignore possible environmental-microbiological origin of the disease.
- Mothers can pass their infections onto their children during pregnancy. Infections in the endometrium of a pregnant mother can most easily penetrate into the body of the fetus.
- Currently, the most prevalent endometrial infections are mycotic and viral infections. This results from the commonly used, frequently inappropriate, antibacterial therapies.
- the most prevalent endometrial cysts, the chocolate ones, are most probably caused by Fusarium; Terbinafine is an effective medicine for such infections;
- sometimes we are dealing with black cysts, which may be caused by mildew fungi (Aspergillus) and can be successfully treated with itraconazole;
- we may also be dealing with mixed infections (Fusarium-Candida, Aspergillus-Candida, etc.), which, if treated one by one, can lead to a more violent expansion of the disease;
- development of endometriosis can also be limited by antibacterial antibiotics such as Bactrim, Cipronex, etc.
Particular types of endometrial infections are manifested in specific symptoms and disturbances in the physiology of the body. Endometrial pain which is a harbinger of menstruation is caused by a sudden development of an inflammation triggered by ischemia in the endometrium if there is an an active infection (mainly with Fusarium or Aspergillus) in the basal layer. Patients with such infections have a tendency to lose weight.
Endometrial pain in the luteal phase can result from active infection with microbes feeding on sugars (e.g. Candida) in the basal layer of the endometrium. In such cases patients have a tendency to put on weight.
During one menstrual cycle two very diverse environments are created in the endometrium, which are friendly for different groups of microbes. One of them feeds on sugars. Such infections cause pain during ovulation and then in the luteal phase. The other group, are microbes feeds on the amino acids and lipids, cause pain just before and during the menstruation. Such infections prolong menstruations.
Hormonal therapy and surgical interventions cannot solve the problem of endometriosis.
Endometriosis negatively affects public health. The health of future generations depends mainly on how healthy the women of child-bearing age are now.
Solving the problem of endometriosis will be the first step towards making the bold, over 100-year-old concept stated below come true:
The doctor of the future will give no medicine, but will instruct his patient in the care of the human frame, in diet and in the cause and prevention of disease - Thomas Edison, 1903.I would like to thank all the users of the http://www.endometrioza.aid.pl/forum/ forum
Reading all the stories about your therapies, fighting for health and becoming mothers provoked me to reflect on this horrible illness and make an attempt to explain its causes. I am deeply convinced that thanks to your work, running this portal will make Thomas Edison's prophecy true much sooner than one could have expected.
Zbigniew Nędzyński is an engineer.
